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Its reduced MC1R affinity means melanocyte stimulation is minimal

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Beyond obvious effects on energy balance, dietary quality can also influence obesity risk through changes in metabolic adaptation due to a high refined carbohydrate diet, in resting energy expenditure (such as through brown or beige adipose tissue thermogenesis), in microbiome calorie utilization (with corresponding greater or lesser utilization by the host tissues), and in epigenetic or trans-generational risk of obesity [87,88]

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Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes