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1 Although the exact cause of OA remains elusive, its hallmark is the breakdown of cartilage and the loss of the crucial extracellular matrix that provides joints with compressive resilience to enable proper function

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Extracellular NAADP + and ADP-ribose might also bind to P2Y receptors and trigger intracellular NAADP + - and ADP-ribose-dependent calcium mobilization (see Calcium mobilization) (15, 16)