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Retatrutide, Mazdutide, and Survodutide are investigational and not approved as finished drugs in any market

Here, we show that YM supplementation selectively enhances GLP-1 gene expression and plasma levels without affecting GIP, and propose a gut microbiota-mediated mechanism as a key driver of these effects. Nutrients 2025, 17, 625

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Because retatrutide simultaneously targets GIP, GLP-1, and glucagon receptors, the authors suggest that studying these combined signaling pathways may help expand scientific understanding of how metabolic and neurological systems interact in preclinical models