Additionally, the healthy worker effect and other biases may attenuate observed associations in prospective designs 306,311
Despite the availability of multiple anti-seizure medications (ASMs) (French and Perucca, 2020), a significant portion of epilepsy patients continues to experience inadequate seizure control and adverse side effects such as depression, psychotic episode, irritability, and aggression (Hixson, 2014
Teschke R, Uetrecht J (2021) Mechanism of idiosyncratic drug induced liver injury (DILI): Unresolved basic issues
Because of this, clinical settings often relied exclusively on intravenous (IV) glutathione or precursor amino acids to raise intracellular levels
However, even with these strategies, plasma concentrations of free parent compounds rarely reach those used in typical in vitro experiments (56)
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