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However, ICIs can cause immune-related side effects (irAEs) by impairing peripheral immunological tolerance, and the endocrine glands are among the organs most frequently impacted

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Seek medical evaluation if constipation persists beyond 3 days, involves severe cramping, blood in stool, or fever above 100.4F, as these may indicate serious underlying conditions

Cytokine (2012) 60:25765

Sleep and recovery signals are reported earliest, within the first weeks