[21] The underlying principle, supported by guidelines from the Endocrine Society, American Association of Clinical Endocrinology, and American Gastroenterological Association, is that obesity is a chronic metabolic disease requiring ongoing medical management
however, trials developed mainly to evaluate the long-term impact of tirzepatide on cardiovascular events, including stroke, are currently in progress [42]
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Epicardial fat expansion in diabetic and obese patients with heart failure and preserved ejection fraction-A specific HFpEF phenotype
50,51 In contrast, quercetin and (-)-EGCG downregulate forkhead box protein O1, reducing the protein levels of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase
Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, et al