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doi: 10.1093/bmb/ldr030 41 FerrariSMRagusaFEliaGPaparoSRMazziVBaldiniEet al

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

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The harmonic restraints were released in five steps, transitioning the system from an NVT to an NPT ensemble over 100 ps