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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

NNMT dysregulation is implicated across obesity, insulin resistance, liver pathology, and other disorders

Even at moderate doses, some individuals may be more sensitive than others

Adopting a healthy lifestyle may partially mitigate the genetic predisposition to HU, with dietary factors playing a smaller but still significant role in serum urate variance and influencing the overall population risk