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Intervertebral Disc Degeneration GLP-1 protects nucleus pulposus cells (NPCs) ( the primary cell type driving disc integrity) by inhibiting AP-1driven catabolic gene transcription (specifically BATF/JUN heterodimers that drive MMP13 and ADAMTS5), curtailing NF-B via SIRT1 upregulation, and differentially modulating STAT3 (suppressing pathological senescence in NPCs while promoting M2 macrophage polarization)

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Each inhibitor was important to establish an early structure activity relationship (SAR) for subsequent investigation

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The magic ingredient here is, of course, collagen, which is fantastic for improving skin elasticity, firmness, and reducing the appearance of fine lines, giving that plump, youthful look