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Because its primary function is to hydrolyze the proteins in your food, the supplement must be present in the stomach at the exact moment the food arrives
If youve been feeling constantly tired, struggling to concentrate, or noticing changes in your mood, it could be more than just stress or lack of sleep
Fundam Clin Pharmacol
Therefore, metformin can achieve glucose-lowering effects via the gut-liver axis and the gut-liver-brain axis, but the first site of metformin action is still the gut, so the gastrointestinal tract remains the main target of metformin action
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