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It occurs in food, is synthesized by the body, and is included in many supplements intended to support metabolism, energy, and recovery

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Inositol supplementation has been shown to preserveor even increaselean mass (gaining up to 7.1% muscle in one arm of a 6month trial), while further enhancing insulin sensitivity (improved HOMAIR scores)

Mutations in the gene encoding OCTN2, SLC22A5 , can impair fatty acid metabolism and lead to systemic primary carnitine deficiency (SPCD, OMIM 212140) 8 , an autosomal recessive disorder whose clinical manifestations include cardiomyopathy, hypoglycemia, chronic muscle weakness and liver dysfunction 9

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