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Ferroptosis inducers can be classified into 4 categories according to their targets, including System Xc-, targeting GSH, targeting GPX4, and targeting ferric ions and ROS

10.3727/105221621X16104581979144 45 JaeschkeH.RamachandranA.ChaoX.DingW

GPX4 reduces phospholipid hydroperoxides (PL-OOH) to their corresponding non-toxic phospholipid alcohol (PL-OH) using GSH as an electron donor, thereby preserving membrane integrity 95

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For example, superoxide dismutases (SODs) convert superoxide O 2