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Molecules 15:432441 Chang KT, Lii CK, Tsai CW, Yang AJ, Chen HW (2008) Modulation of the expression of the class of glutathione S-tranferase by Adrographis paniculata extracts and adrographolide

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For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes