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Lipid peroxidation drives gasdermin d-mediated pyroptosis in lethal polymicrobial sepsis

This insulin release tapers off as blood glucose levels normalize, reducing the risk of hypoglycemiaa common risk with other diabetes medications

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Blood glucose was measured before dosing and at 30 min, 1, 2, 4, 6 h after dosing in fed conditions

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In agreement with our immunoblotting analysis, we observed an induction of CHAC1 under cystine starvation in CHAC1 expressing H1299 cells but not those subject to CRISPR/Cas9-mediated CHAC1 knockout 48 , indicating antibody specificity (Supplementary Fig