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Early effects may appear within a few weeks, while more noticeable fat loss often occurs after 2 to 3 months

Key Highlights: ~23% mean weight loss at 84 weeks Studied in adults with obesity + 1 comorbidity

33 demonstrated that Gli2 is the key mediator of Shh responses in the skin, and Gli2 controls epithelial cell proliferation in embryonic skin through transcriptional regulation of cyclin D1 and D2, we believed that Shh signaling participated in the process of active hair-follicle density increase through Gli2

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This reduces lipid peroxidation and maintains motility