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Furthermore, as shown in Figure 1C, the important upstream side of the known M pro cleavage site at the nsp13/14 junction, NVATLQ/A, is remarkably similar to that of the active site sequence of GPx1, NVASLU/G, where the selenocysteine (U) lines up with a glutamine (Q) in the viral sequence

Since SF3B1 phosphorylation occurs in tandem with the formation of a catalytically active U2/U6 RNA structure (i.e., from B to B act ) 8,12 , P-SF3B1 may also help to stabilize this structure during the activation process

Bioavailability refers to how much of a substance actually enters your bloodstream to be used by your body

PMCID: PMC5413479

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