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These varying evidence sources possess distinct bias structures: RCTs provide average efficacy under ideal conditions but often exclude high-risk or complex patients

General guidance in this article does not supersede these sources

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Mounjaro Mounjaro represents the next generation of weight loss medication

Nausea or vomiting occurs in 3 to 8 percent of GLP-1 trial participants, but the vast majority resolve without discontinuing therapy

Where appropriate, cognitive behavioural therapy can help to control impulsive eating behaviours, while bariatric surgeries or injectable weight loss drugs might be recommended in urgent cases 13