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The exact mechanism is not fully understood and varies between individuals

Intra-patient escalation dosing strategy with IMCgp100 results in mitigation of T-cell based toxicity and preliminary efficacy in advanced uveal melanoma

Finally, the GSH/GSSG ratio was then calculated by subtracting the measured GSSG value from the total GSH content, as described previously [32]

2010 Mar;95(3):1309-17 33i

The authors thought that comparing the studied parameters before and after administration of LC is appropriate to test the effects of LC on the same individual of rams (to avoid individual variations)

however, rare complications can extend symptoms even longer