The FDA-approved oral formulation (Rybelsus for diabetes, Wegovy pill for weight loss) has been clinically validated but requires much higher doses than injectable versions
A clinical trial in 2015 linked an undisclosed GLP-1 to significant improvements in OSA severity, while a 2016 clinical trial found that weight loss resulting from liraglutide was significantly associated with a reduction in the apnea-hypopnea index (AHI)
Patients with a history of eating disorders, seizures, uncontrolled hypertension, or current use of opioid medications should avoid Contrave due to contraindications and safety concerns
For many patients, a better metabolic plan means fewer cravings, more stable energy, improved health markers, and a more realistic path to long-term weight control
Patients on GLP-1s who are not doing any resistance training are losing more muscle than they need to
However, when it is in excess, these benefits are overcome by a pro-inflammatory activity, being associated with worse haemodynamic and metabolic profile in patients affected by HFpEF [35, 36]
