One aspect of it is that only about 40 percent of people are on medications after a year, and we dont know why, continues Holst
The side effect profile at the 12mg dose includes nausea (28% of participants), diarrhea (23%), constipation (17%), and vomiting (12%)
This is a complex question that depends heavily on the specific peptides stability
Li B, Li Y, Zhou H, Xu Y, Cao Y, Cheng C, et al
While the mid-regions of both peptides interact with the top of TM1/ECD stalk, the ECD, ECL1 and the top of TM2, exendin-4 exhibits more persistent interactions in the simulations, particularly with the TM1/stalk and ECD (Supplementary Tables 1 and 3)
Clinical safety: Use only by the current labelled topical route