semaglutide nepal Denmark to restrict Ozempic, other GLP-1 drugs, to treat type 2 diabetes Comparative Efficacy and Safety of

doi: 10.1002/pros.20850

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Diabetologia 2002;45:11111119 EXENATIDE AND LIRAGLUTIDE Effectively reduce HbA1c Preserve beta cell function Promote weight loss Correct known pathophysiologic defects in T2DM Do not cause hypoglycemia Have an excellent safety profile Rad 03/20/00 Triplitt & DeFronzo, Expert Rev Endo Metab 1:329-41, 2006 TIME COURSE OF EFFECT OF EXENATIDE ON HbA1c Time (weeks) 0 20 40 60 80 156 0.5 Placebo Baseline HbA1C=8.3% 0 Exenatide- 10 g bid DeFronzo et al, Diabetes Care 28:1092-1100, 2005 D HbA1c (%) Klonoff et al, Curr Med Res Opin 24:275-285, 2008 -1.0 Exenatide- 10 g bid -2.0 Open-Label Extension Placebo-Controlled Trials EFFECT OF EXENATIDE VERSUS GLARGINE INSULIN ON INSULIN SECRETION IN T2DM Subjects: 59 T2DM

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Staggered administration: Compounds with potentially competing mechanisms or absorption may benefit from temporal separation