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Of note, in the DIRECT study, carriers of p.S539W had an independently significant reduction in response to GLP-1RA (-0.67% (7.3 mmol/mol) per allele, p = 0.034)
Weight loss is a valuable outcome and worth optimizing
Take care to store semaglutide properly, and dont use improperly stored semaglutide (such as Ozempic pens left in the car)
Probiotics may help with digestive health and can be beneficial if gastrointestinal symptoms occur
Yet, there are still many unanswered questions surrounding their use and long-term effects
The post describes the effect as dose-dependent, with higher doses and faster titration schedules raising the likelihood
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