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doi: 10.1007/s13300-021-01116-9 13 AndreasenCRAndersenAKnopFKVilsbllT
2 Mounjaro produced 20.2% in that same trial
Can dehydration from GLP-1 medications harm my kidneys
And why instead of forgoing participation are they lowering their net price to the same (or nearly the same) level as Xarelto
A 2024 study in ex vivo follicles showed GHK-Cu upregulated -catenin by 40%, rivaling valproic acid (Lee et al., 2024)
Semaglutide (Ozempic/Wegovy) Timeline Phase 3 trials began: 2015 (SUSTAIN program for diabetes) FDA approval (Ozempic for diabetes): December 2017 Commercial availability: Early 2018 Wegovy (obesity indication) Phase 3: 2018-2020 (STEP program) Wegovy FDA approval: June 2021 Wegovy commercial launch: September 2021, immediately went into shortage due to overwhelming demand Stable widespread availability: Mid-2023 (after Novo Nordisk scaled up manufacturing) Total time from Phase 3 start to stable availability: About 8 years for diabetes indication, 5 years for obesity indication (but with significant supply constraints)
