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Combination nutraceuticals Metanx : Metanx is a prescription medical food containing L-methylfolate, methylcobalamin, and pyridoxal-5-phosphate

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Since an IV dose is administered directly into the systemic circulation, it is assumed to have 100% bioavailability, or F = 1 and provide the reference standard for comparisons

Kureishi, Y

In experimental models for the induction of tissue damage, 20 mg/kg MTX was a commonly used dose for rats (Reference Moodi, Hosseini and Abedini16Reference Azadnasab, Kalantar and Khorsandi20)

The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A