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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

*Average weight loss based on 68 and 72 week clinical trials studying semaglutide (2.4 mg) and tirzepatide (10-15 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related health condition, the average weight loss was 15% and 20% respectively

Patients already managing five or more daily medications may also do better on a weekly shot

M.DjuriJ.ProtrkaZ.ArsenijeviS.et al (2019)

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Summary of differences between Sermorelin, Ipamorelin, and Tesamorelin in research contexts. Mechanism of Action Difference s Sermorelin Mimics endogenous GHRH to trigger physiologic GH pulses. Preserves negative feedback loops via somatostatin