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Cartilage is not designed for high stress loads that it will see with obesity. The new study, which was funded by Novo Nordisk, included about 400 patients with knee osteoarthritis, with an average age of 56, in 11 countries

Lin C, Sang Q, Fu Z, Yang S, Zhang M, Zhang H, et al

Common adjustments at this phase include modifying injection day to optimize appetite suppression timing, splitting dietary intake into smaller, more frequent meals, and adding electrolyte supplementation if GI side effects cause fluid imbalances

2014;3(6):e001202

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Subject to meeting the coverage criteria, some BCBS plans cover Zepbound and other GLP-1 agonist weight loss medications, but BCBS Michigan will not offer coverage for GLP-1 weight loss drugs starting from January 1, 2025