Side effects tend to be most intense during this period, particularly during the first weeks of tirzepatide treatment and during each dose escalation
Unopened semaglutide pens last until the manufacturer expiration date when refrigerated, and can survive at room temperature for limited periods
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A patient with prediabetes may see fasting glucose improve first, then A1C, then broader changes in energy, cravings, waistline, and cardiovascular risk markers
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Split dosing Some clinicians divide the weekly dose into two smaller injections, typically given three to four days apart