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Limitations include: Enzymatic and chemical degradation Poor membrane permeability Comparatively large molecular size When a peptide like epithalon is unmodified, bioavailability may be less than 1%

Biochem J 431:16978 Garca-Gimnez JL, Markovic J, Das F, Queval G, Schnaubelt D, Foyer CH, Pallard FV (2013) Nuclear glutathione

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