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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity
In addition, CYP24A1-mediated inactivation of Vitamin D has also been implicated as a critical factor in pathological skin processes
The acute respiratory distress syndrome: pathogenesis and treatment
