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Consistent medication levels : Maintained throughout the week without the peaks and valleys of oral medications
We assumed a minimum reduction in HbA 1c of 5.5 mmol/mol (0.5%) and in body weight of 4.5 kg (5% of mean body weight value at baseline across all trials) as clinically important [18]
The GLP-1 receptor activation partially bypasses leptin pathways, maintaining appetite suppression even as leptin drops
It also matters for accuracy at high doses, because you can fit the entire dose within a 1 ml syringe up to 20 mg
The larger benefit with the additional agonism of GIPr seems to be its effect on weight loss
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