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In obese mouse models, liraglutide improved insulin sensitivity in visceral adipose tissue, which was associated with reduced endoplasmic reticulum stress and increased Akt phosphorylation following insulin stimulation ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

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Social Skills Interventions There are many social skills interventions for individuals with ASD, but designing research to measure the effectiveness of these interventions is challenging, and there is not much supporting research evidence