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The company says the results were strong enough to launch an extensive Phase 3 development program that will include obesity, type 2 diabetes, cardiovascular outcomes, and kidney disease studies

2,3,4 These improvements are seen whether LEGEND is administered by intravenous (I.V.) or intra-articular (I.A.) injection

Dry mouth, insomnia, increased heart rate, and restlessness are the most commonly reported issues

10.1007/s12011-020-02515-y 71 WangX.HanY.ChenF.WangM.XiaoY.WangH.et al (2022)

reported that semaglutide may contribute to a higher risk of intensity of retinopathy (particulary in diabetics with existing retinopathy), with a rapid reduction in hemoglobin A1c levels and a higher rate of progression of proliferative retinopathy, as well as risk of new-onset macular edema [44]

The choice depends on your goals, budget, and body