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Dapiglutide is one of the first agents in this emerging generation of weight-loss drugs

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Even then, the addition should be short-term with clear success criteria and a defined discontinuation timeline

For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]