A synthetic analog of IGF1, mecasermin, is used for the treatment of growth failure in children with severe IGF1 deficiency
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See recent WSJ article here Enthusiasts (biohackers?) and some longevity-focused clinicians believe that microdosing these drugs offers benefits beyond weight loss, such as improved metabolic health, glycemic control, reduced systemic inflammation, and potentially even a lower risk of age-related diseases
doi: 10.2337/diabetes.52.1.102 [DOI] [PubMed] [Google Scholar] 125
If the patient is scheduled for surgery with a moderately high risk of bleeding, direct factor Xa inhibitors should be held for at least 48 hours before the procedure (1)
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