Our results using C-tail swapped GIP receptors are, in part, in agreement with the findings of a recent study that investigated the role of GIPRs C-terminal tail in signaling and internalization in different species
The measures of systolic blood pressure, systemic inflammation (as measured by high-sensitivity C-reactive protein levels), blood lipid profile, insulin resistance, AHI and event-specific hypoxic burden all improved for those treated with tirzepatide compared with placebo
In addition, in order for these drugs to become a public health tool for cancer treatment or prevention, more information would be necessary such as what cancers are most affected by GLP-1s, how long patients need to remain on therapy for the desired protection and whether benefits differ between different GLP-1 medications
Drug Metabolism Dispos
, 30
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