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Other studies have demonstrated that hyperglycemia not only downregulates both Glp-1 et Gip receptors expression in pancreatic islets but also impairs Glp-1 signaling pathway through the loss of Glp1r at the -cell cytoplasmic membrane (63)

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Tirzepatide Tirzepatide (Mounjaro) is another peptide that is approved by the FDA for type 2 diabetes and works by stimulating insulin secretion, suppressing glucagon, and reducing appetite