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Moreover, A double-blind study of patients with T2DM treated with metformin led to significant changes in the relative abundance of more than 80 bacterial species compared with placebo after 4 months, in which an increase in Escherichia and Akkermansia muciniphila and a decrease in Intestinibacter were also observed, whereas most of the changes with placebo occurred in phylum Firmicutes and phylum Proteobacteria (Wu et al., 2017)

These results are often better than what people see with diet and exercise alone or some other medications

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Gut microbial metabolite trimethylamine N-oxide is related to thrombus formation in atrial fibrillation patients

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PMC 7756841