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While the structural basis of GLP-1R biased agonism between arrestin recruitment and G protein pathways is still not clear and will require additional studies to decipher, there is growing evidence that biased agonism is associated with the conformation and dynamics of the TM6/ECL3/TM7/TM1 domain 3, 14, 16, 27, 29 , and this is consistent with the data presented herein

The most likely reason for incapacity to synthesize carnitine from lysine and methionine is inability to convert -butyrobetaine to carnitine [68]

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Abbreviations: DBPC, double-blind placebo-controlled

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