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The brain is orders of magnitude more complex than muscle tissue, and the interactions between multiple neuroactive compounds are not always predictable

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By concurrently modulating metabolic dysfunction and inflammatory signaling, GLP-1RAs could potentially reduce the required doses of biologics or other immunosuppressive therapies, thereby minimizing treatment-related toxicity while improving overall disease control

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In addition, diuretics are frequently used during cutting or contest preparation to reduce water retention, increasing the risk of dehydration, electrolyte disturbances, arrhythmias, and acute kidney injury (92, 95)