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But there are a few outstanding gray areas
& Wolfe, S
NICE guidance (NG238) does not currently recommend GLP-1 receptor agonists specifically for dyslipidaemia treatment, though their cardiovascular benefits are recognised in appropriate patient populations
Instead of feeling too depleted to exercise or too foggy to make good choices, users feel capable and engaged
Common adverse effects include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, constipation, and abdominal pain (affecting up to 40% of users) Reduced appetite and weight loss Injection site reactions redness, itching, or discomfort Hypoglycaemia particularly when used alongside insulin or sulfonylureas More serious but rare adverse effects include pancreatitis (inflammation of the pancreas) and gallbladder disease
Moreover, GLP-1RA negatively influences the expression of peroxisome proliferator-activated receptors (PPARs), leading to a downregulation of proteins associated with lipid metabolism (37, 41, 42)
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