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In the meantime, it is timely to reinforce the message in guidelines to use currently available medicines as effectively as possible to counter the ever-present challenge of hyperglycaemia + time = complications

Fatigue, depression, and sleep disorders are more prevalent in patients with metabolic-associated fatty liver diseases

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This reduces long-term medication costs, minimizes ongoing side effects, and preserves the option to escalate again if needed

While natural GLP-1 rarely causes problems, pharmaceutical GLP-1 agonists commonly cause gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation, particularly during dose escalation

Br J Dermatol 2009