The general reaction involves formation of an unsymmetrical disulfide from the protectable protein (RSH) and GSH: [24] RSH + GSH + [O] GSSR + H 2 O Glutathione is also employed for the detoxification of methylglyoxal and formaldehyde, toxic metabolites produced under oxidative stress
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Huang D, Shen P, Wang C, Gao J, Ye C, Wu F
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
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While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals
