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Higher body weight means more tissue distribution for the medication, which can blunt the effects of lower doses

Phage therapy targeting this bacterium effectively alleviated steatohepatitis, improved liver function, and reduced the expression of inflammatory cytokines and lipogenic genes in mouse models, without causing significant pathological changes in liver/kidney function or gut flora composition, proving its efficacy and safety

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Apart from the greater efficacy for both glucose lowering and weight loss, not very