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PUFAs are among the primary targets of lipid peroxidation, and lipid synthesis-mediated production of PUFAs increases cellular sensitivity to ferroptosis ( 2 ) on the plasma membrane and mitochondrial inner membrane, respectively

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Retatrutide is a peptide-based molecule essentially a chain of amino acids

An enzymatic assay was also performed to quantify total and oxidized glutathione levels from homogenized tissue