Why mitochondria matter As you might recall from your high school biology textbook, mitochondria are considered the powerhouses of the cell because of their role as energy suppliers, intercellular signalers, and metabolic coordinators.3 As such, theyre central to a biological process called apoptosis (cell death), which involves the disposal of damaged or abnormal cells.4 Also, apart from the nucleus, mitochondria are the only other parts of a human cell that carry DNA.5 Therefore, mitochondrial dysfunction is inextricably linked to health conditions stemming from cellular breakdown and chromosomal changes, both of which correlate with aging.6 7 Apart from primary mitochondrial diseases such as Leigh syndrome and MELAS syndrome, these health conditions include but arent limited to:8 9 10 Cancer Diabetes Heart disease Kidney diseases Neurodegenerative disorders (e.g., Alzheimers and Parkinsons) Hearing loss Eyesight abnormalities Oxidative stress Metabolic imbalance Inflammation Myalgic encephalomyelitis, or ME/CFS (potentially
Cardiac biomarkers including NT-pro-BNP and troponin levels are extremely high compared to historical KD cohorts and indicate heart failure and myocardial damage in MIS-C
The formalin test: characteristics and usefulness of the model
10.1002/dta.3225 41 PiatkowskiT.PuljevicC.FrancisC.FerrisJ.DunnM
Evidence from primary-care and community-based cohorts indicates that structured, non-pharmacological interventionscentred on individualized medical nutrition therapyconstitute an indispensable pillar for achieving sustained metabolic control in T2DM (153)
Brussels, Belgium: 2015
