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Because exercise cannot be treated as an optional lifestyle recommendation, future weight loss protocols must pair the medication with structured behavioral interventions to enforce muscle-preserving movement

With increasing serine levels, serine functions as an allosteric activator of PKM2, supporting aerobic glycolysis and regulating either pyruvate conversion to lactic acid or pyruvate catabolism into the tricarboxylic acid (TCA) cycle [22, 23]

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Uninfected controls were included to check for damage from cysteine or BSO treatment alone

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Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition