At Affinity Whole Health , we offer both compounded semaglutide and compounded tirzepatide
Pen vs Vial Considerations Mounjaro comes only in pre-filled pens at retail pricing
Injectable GLP-1s: Nearly 100% bioavailability Consistent, predictable absorption Doses of 1-2.4mg weekly for semaglutide FDA-Approved Oral Tablets: 0.4-1% bioavailability Requires 7-25mg doses to achieve similar effects Must be taken with specific timing and fasting requirements Compounded ODT Formulations: Theoretical bioavailability advantage over swallowed tablets Sublingual/buccal delivery bypasses stomach acid and first-pass metabolism However, research on peptide delivery shows challenges: peptides may be degraded by salivary enzymes, have poor permeability due to large molecular size, and face continuous wash-away from saliva No clinical trials have established actual bioavailability or effectiveness for compounded GLP-1 ODTs These formulations are not FDA-approved and haven't undergone rigorous testing The theoretical advantage of ODT formulations is that by dissolving in the mouth rather than the stomach, they could achieve better absorption than swallowed tablets while maintaining the convenience of a daily, needle-free option
Clinical trials have shown promising results, with participants achieving weight loss of 15 to 20 percent over a period of 72 weeks
A vial of lyophilized tirzepatide sitting in your fridge might be good for a year
Notice the "percentage of starting dose" column
