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This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction

ROS can modify sperm proteins, leading to structural changes that impair motility, metabolic processes, and the sperms ability to bind to the oocyte

doi: 10.1111/j.1369-1600.2006.00041.x 17 KanjiS.FonsekaT

doi: 10.1097/PAS.0b013e318057faa7 86 FerraraGDe VannaAC