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This activates NF-B to trigger neuroinflammation, ultimately exacerbating SNpc dopaminergic neuron apoptosis in PD (162)

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Finally, an important issue with GLP-1 receptor agonists is their potential to cause loss of lean body mass (fat-free mass)

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Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, Chavey WE, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC, Jacobs AK, Adams CD, Anderson JL, Antman EM, Halperin JL, Hunt SA, Krumholz HM , Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B