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NRF1 expression is upregulated in denervation-induced muscle atrophy (Supplementary Appendix Figure 2

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GSH is the most important antioxidant and free radical scavenger that is found to be decreased in the brains of people with a wide range of mental and neurological illnesses from schizophrenia (4) to dementia (5, 6)

The copper complex gives a distinctive blue colour to reconstituted solution characteristic of bound copper

Interestingly, IPA software predicted an inhibition of oxidative phosphorylation in metformin treated SW837 cells, supporting the demonstrated metformin-induced inhibition of OCR using Seahorse live-cell metabolic profiling ( Figure 1 )